Prerequisites
This cumulative update requires Microsoft .NET Framework 4.8.
A component that's used within Exchange Server requires a new Visual C++ component to be installed together with Exchange Server. This prerequisite can be downloaded at Visual C++ Redistributable Packages for Visual Studio 2013. For more information, see KB 4295081.
For more information about the prerequisites to set up Exchange Server 2016, see Exchange 2016 prerequisites.
Restart requirement
You may have to restart the computer after you apply this cumulative update package.
Registry information
You don't have to make any changes to the registry after you apply this cumulative update package.
Removal information
After you install this cumulative update package, you can't uninstall the package to revert to an earlier version of Exchange Server 2016. If you uninstall this cumulative update package, Exchange Server 2016 is removed from the server.