However, in an Exchange 2003 and Exhange 2007 mixed environment, if an Exchange 2003 user sets safe senders in Outlook, you cannot update the safe sender list for this user. For example, you may run the Update-SafeList cmdlet in Exchange Management Shell to update the safe sender list for a user:
Update-SafeList -Identity "<exchange 2003 mailbox>"
Update-SafeList : Property
SafeSendersHash cannot be set on this object because it requires the object to
have version 0.1 (8.0.535.0) or later. Current version of the object is 0.0
(6.5.6500.0)