You must specify domain groups and user accounts when you install BizTalk Server in a multiple computer environment

If you install Microsoft BizTalk Server on multiple computers, you must specify domain global groups and domain user accounts in the BizTalk Server Configuration Wizard. For example, if you install multiple BizTalk Server computers in a BizTalk Server Group and if the Microsoft SQL Server that houses your BizTalk Server databases is on a remote computer, or if one of these cases is true, you must specify domain global groups and domain user accounts.

For more information, see the online BizTalk Server 2006 documentation at the following Microsoft Developer Network Web site: For more information, see the online BizTalk Server 2004 documentation at the following Microsoft Developer Network Web site:Note If you use domain groups for your BizTalk Server configuration, you must manually create the groups before you configure BizTalk Server. If you configure BizTalk Server to use domain groups, you must create and specify domain global groups. If you use local groups, the BizTalk Server Configuration Wizard will create the specified groups for you.