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Microsoft BizTalk Server 2016 Feature Packs support 32-bit hosts running on 64-bit machines.
This problem is fixed in the following cumulative update for BizTalk Server:
For information about the service packs and cumulative update list for BizTalk Server, see the following article in the Microsoft Knowledge Base:
2555976 Service Pack and cumulative update list for BizTalk Server
For more information about BizTalk Server hotfixes, see the following article in the Microsoft Knowledge Base:
2003907 Information about BizTalk hotfixes and Cumulative Update support
Keywords: kb, kbfix, kbqfe, Support not available for BizTalk Server Feature packs on 32-bit machines, kbHotfixAuto, CI98431