After installing the March 5, 2018 update for Windows 10, KB4090913 (OS Build 16299.251), you may experience an error message when attempting to launch or install Windows Mixed Reality.
With Windows Mixed Reality already installed, when you attempt to launch the Mixed Reality Portal you may receive the error, "Something went wrong."
When installing or reinstalling Windows Mixed Reality you may receive an error, “We couldn’t download Windows Mixed Reality."