If you try to call CoCreateInstance() with a CLSID of CLSID_InternetExplorer multiple times, you eventually see CoCreateInstance() return seemingly random failure HRESULTs, including E_NOINTERFACE and E_CLASS_NOT_REG. You may also see strange windowing behavior through the operating system; for example, the All Programs window on the Start menu does not open when you select it.
This problem is most relevant to applications that automate Internet Explorer and that require multiple instances of the browser to run at one time, such as load-testing applications.
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