In an Exchange 2016 environment, your organization has lots of Accepted Domains. MSExchangeOWAAppPool application pool may consume a very large amount of memory every time that it recycles on schedule or manually.
Additionally, the MSExchangeOWAAppPool application pool is marked as unresponsive by Health Manager and the Outlook Web Access (OWA) client might be unable to connect to OWA.
Additionally, the MSExchangeOWAAppPool application pool is marked as unresponsive by Health Manager and the Outlook Web Access (OWA) client might be unable to connect to OWA.