When the best practices are followed, the version coexistence issues of the applications are minimized and the locally installed version of Office acts as the “Primary version” and is registered to handle the File Type Associations (FTA) with Windows. The virtual version of Office does not handle the FTAs, because they are removed from the virtual applications. Application Virtualization shortcuts should be created to launch the virtual version. A typical scenario where this would be implemented is when a line of business application is dependent on a specific version of Office that is different than the “Primary version”.
If the virtual version of an application is running and a user clicks on a file with an associated extension, it may open in the virtual version of the application. When launching an application from file type associations, Windows will check for applications that support that File Type Association that are already running.