Applications whose manifests specify automatic elevation (for example mmc.exe) may require additional steps to work correctly using run-as in App-V environments. This is a common scenario for environments that require using separate credentials from the account used to log on to the desktop. For instance, a normal user account may be used to log on to a Windows 7 Professional desktop, and then a second account with administrative rights may be used to launch the System Center Configuration Manager (ConfigMgr) Administration Console by shift-right-clicking on the shortcut and choosing Run as different user.
Errors will vary depending on the application. For the Configuration Manager console, the MMC may fail to load with the error: Error initializing console.